Press Left or Right at the main menu to display a ½ symbol appear next to player one. Press Start to begin game play.
Note: This is the classic Game Boy game, not to be confused with Ms. Pac-Man for the Game Boy Color.
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We have Ms. Pac-Man cheats for Game Boy and Xbox 360 on CheatCodes.com. Give them a try, since cheats for other game systems sometimes work on Game Boy games, too!