Plague Inc. Hints, Tips, Tricks, Secrets, & Glitches

Symptom Combo List

  • Oops: Sneezing + Diarrhea: Lowers productivity and increases awareness
  • Profuse Bleeding: Hemophilia + Skin Lesions: Infectivity++
  • Projectile Vomiting: Coughing + Vomiting: Infectivity
  • Public Defecation: Diarrhea + Insanity: Increase Research Speed (*** BEWARE ***)
  • Swine Flu: Nausea, Pneumonia, Vomiting, Diarrhea, Coughing, Sneezing, Insomnia, Paranoia, Livestock 1 & 2: Decrease Research Speed (10% increase in budget required for cure)
  • Walking Dead: Anemia + Insomnia: Decrease Research Speed


  • Necroa Virus Symptom Combos
  • Bath Time: Polyphagia + Autophagia + Cannibalism: Severity
  • Blood in the Air: Delirium + Hyperosmia: Severity
  • Boomer: Liquefied Organs + Authothysis: Severity
  • Cranial Dispersion: Cranial Elephantitis + Air 3: Transmission (?)
  • Tank: Anabolic Boost + Bone Dysplasia: Severity
  • Spitter: Naja Mortis + Enhanced Sensory Integration: Severity
  • Sprinter: Enhanced Movement Control(?) + Engorged Quadriceps: Severity
  • Walking Contradiction: Photophobia + Cathemeral Shift: Severity Decreased
  • Vampire Bat: Bat 2 + Vampiric Hunger: Severity; alerts zombies of nearby humans
  • Symptom Upgrade List

  • Abscesses: Transmission; [unlock] Systematic Infection, Tumors
  • Anemia: Infectivity, Severity; [unlock] Hemophilia
  • Coma: Lethality, Cure Defense++; [unlock] Paralysis, Systematic Infection, Total Organ Failure
  • Coughing: Transmission in Urban Regions; [unlock] Pneumonia, Sneeze
  • Cysts: Transmission; [unlock] Abscesses, Hyper Sensitivity
  • Diarrhea: Transmission, Transmission++ in Poor Regions, Lethality, Lethality++ in Poor Regions; [unlock] Dysentery, Pulmonary Edema, Vomiting
  • Dysentery: Transmission, Lethality; [unlock] Diarrhea, Insanity
  • Fever: Infectivity, Lethality; [unlock] Immune Suppression, Skin Lesions, Sneezing, Sweating
  • Hemophilia: Transmission; [unlock] Internal Hemorrhaging, Tumors
  • Hemorrhagic Shock: Lethality; [unlock] Internal Hemorrhaging, Necrosis
  • Hyper Sensitivity: Severity, Severity++ in Rich Regions; [unlock] Inflammation, Paralysis
  • Immune Suppression: Mutation, Lethality; [unlock] Fever, Sneezing, Total Organ Failure
  • Inflammation: Lethality; [unlock] Hyper Sensitivity, Paralysis, Paranoia, Seizures
  • Insanity: Cure Defense++; [unlock] Dysentery, Seizures
  • Insomnia: Severity; [unlock] Paranoia
  • Internal Hemorrhaging: Lethality; [unlock] Hemophilia, Hemorrhagic Shock, Tumors
  • Nausea: Severity, Transmission; [unlock] Vomiting
  • Necrosis: Lethality, Transmission; [unlock] Hemorrhagic Shock, Skin Lesions
  • Paralysis: Cure Defense++, Lethality; [unlock] Coma, Hyper Sensitivity, Inflammation
  • Paranoia: Severity; [unlock] Inflammation, Seizures
  • Pneumonia: Severity in Cold Climates; [unlock] Pulmonary Edema, Pulmonary Fibrosis
  • Pulmonary Edema: Lethality, Transmission; [unlock] Diarrhea, Pneumonia, Pulmonary Fibrosis, Vomiting
  • Pulmonary Fibrosis: Lethality; [unlock] Pulmonary Edema, Pneumonia, Total Organ Failure
  • Rash: Infectivity; [unlock] Sweating
  • Seizures: Lethality; [unlock] Inflammation, Insanity, Paranoia
  • Skin Lesions: Transmission++; [unlock] Fever, Necrosis, Sweating
  • Sneezing: Infectivity++; [unlock] Fever, Immune Suppression
  • Sweating: Transmission, Transmission++ in Cold Climates; [unlock] Fever, Skin Lesions
  • Systematic Infection: Transmission++, Lethality; [unlock] Abscesses, Coma, Tumors
  • Total Organ Failure: Lethality++; [unlock] Coma, Immune Suppression, Pulmonary Fibrosis
  • Tumors: Lethality; [unlock] Abscesses, Hemophilia, Internal Hemorrhaging, Systematic Infection
  • Vomiting: Transmission; [unlock] Dysentery, Pulmonary Edema
  • Transmission Upgrade List

  • Air 1: Infectivity in Arid Climates, Plane Transmission; [unlock] Air 2
  • Air 2: Infectivity in Arid Climates, Plane Transmission; [unlock] Extreme Bioaerosol if Water 2 upgraded
  • Bird 1: Infectivity, Land Transmission, Mutation; [unlock] Bird 2
  • Bird 2: Infectivity, Land Transmission, Mutation; [unlock] Extreme Zoonosis if Livestock 2 and Rodent 2 upgraded
  • Blood 1: Infectivity in Poor Regions, Mutation; [unlock] Blood 2
  • Blood 2: Infectivity in Poor Regions, Mutation; [unlock] Extreme Hematophagy if Insect 2 upgraded
  • Extreme Bioaerosol: Infectivity, Infectivity++ in Humid and Arid Climates, Plane and Ship Transmission++
  • Extreme Hematophagy: Infectivity, Infectivity++ in Poor Regions, Mutation
  • Extreme Zoonosis: Infectivity, Infectivity++ in Rural and Urban Regions, Mutation, Cross-Country Transmission++
  • Insect 1: Infectivity in Hot Climates, Mutation; [unlock] Insect 2
  • Insect 2: Infectivity in Hot Climates, Mutation; [unlock] Extreme Hematophagy if Blood 2 upgraded
  • Livestock 1: Infectivity in Rural Regions, Mutation; [unlock] Livestock 2
  • Livestock 2: Infectivity in Rural Regions, Mutation; [unlock] Extreme Zoonosis if Bird 2 and Rodent 2 upgraded
  • Rodent 1: Infectivity in Urban Regions, Mutation; [unlock] Rodent 2
  • Rodent 2: Infectivity in Urban Regions, Mutation; [unlock] Extreme Zoonosis if Bird 2 and Livestock 2 upgraded
  • Water 1: Infectivity in Humid Climates, Ship Transmission; [unlock] Water 2
  • Water 2: Infectivity in Humid Climates, Ship Transmission; [unlock] Extreme Bioaerosol if Air 2 upgraded
  • Play In Fast Forward

    Sometimes near the end, it can take a while for anything to happen (get more DNA points, etc.), so you can speed up the game. You do that by clicking on the date box near the top-right of the screen. You can then play quicker. The pop-up bubbles will stay longer, so you don't have to worry about popping them in time.

    Plague Inc. Unlockables & Awards

    Necroa Virus

    You can unlock the "Necroa Virus" by beating all the other plagues. Buy you must do it while playing in "Brutal" mode as the difficulty.

    Plague Type Unlocks

  • Beat ALL 8 Plague types on Brutal Difficulty : Immune Plague
  • Beat ALL 8 Plague types on Brutal Difficulty : Hidden Plague
  • Beat ALL 8 Plague types on Brutal Difficulty : Unlimited Plague
  • Unlockable Virus Types

  • Bio-Weapon : Beat Nano-Virus Plague type on Normal or Brutal Difficulty, OR pay US$0.99 after unlocking Nano-Virus
  • Fungus : Beat Virus Plague type on Normal or Brutal Difficulty, OR pay US$0.99 after unlocking Virus
  • Nano-Virus : Beat Prion Plague type on Normal or Brutal Difficulty, OR pay US$0.99 after unlocking Prion
  • Neurax Worm : Beat all 7 plague types on Brutal Difficulty only, OR pay US$1.99
  • Parasite : Beat Fungus Plague type on Normal or Brutal Difficulty, OR pay US$0.99 after unlocking Fungus
  • Prion : Beat Parasite Plague type on Normal or Brutal Difficulty, OR pay US$0.99 after unlocking Parasite
  • Virus : Beat Bacteria Plague type on Normal or Brutal Difficulty, OR pay US$0.99